Principal Scientist, Biochemist/Biophysicist Job at Kodiak Sciences, Palo Alto, CA

WHEyUm1FenV6dlQrYjNLUkJ0MjN1NXpvTWc9PQ==
  • Kodiak Sciences
  • Palo Alto, CA

Job Description

Kodiak Sciences Inc. is a fast-growing, clinical-stage biopharmaceutical company focused on transforming ophthalmology through innovative therapeutics. Our Antibody Biopolymer Conjugate Drug (ABCD) platform combines protein engineering, polymer chemistry, small molecule drug discovery, bioconjugation, and drug delivery to address high-prevalence ophthalmic diseases.

We are seeking a motivated and independent Biochemist/Biophysicist to join our Discovery Medicine group as part of the Protein Engineering team. The team is responsible for designing, engineering, and characterizing antibodies and novel drug formats for retinal disease treatment. The successful candidate will play a key role in driving research efforts for our drug pipeline extension. This is an exciting opportunity to contribute to cutting-edge therapeutics development in a dynamic, interdisciplinary environment.

Responsibilities

  • Design, build and characterize peptide- and protein-based therapeutic candidates.
  • Conduct peptide discovery and optimization campaigns, including implementation of display platforms.
  • Develop and apply biophysical and biochemical assays to evaluate binding, stability, aggregation, and structure of therapeutic molecules.
  • Design and interpret experiments involving site-specific bioconjugation and chemical modifications, supporting the generation of novel formats, including multivalent constructs and targeted delivery vehicles.
  • Contribute scientific insight to guide pipeline advancement, project direction, in collaboration with cross-functional teams.

Qualifications

Education

  •  PhD in Biochemistry, Biophysics, Molecular Biology or related disciplines.
  • 5+ years or relevant experience in an industry setting

Required Skills

  • Strong expertise in protein biochemistry, including recombinant protein expression, purification, characterization, and structure-function analysis.
  • In-depth knowledge of linear and constrained peptides, including incorporation of unnatural amino acids, peptide discovery platforms (e.g. mRNA display), along with HPLC, LC-MS, NMR and CD for structural and functional characterization.
  • Demonstrated experience with click chemistry and other-site specific bioconjugation methods, particularly in the context of protein, peptides, oligonucleotides, or targeted delivery applications.
  • Hands-on experience with biophysical/biochemical characterization techniques, including SPR, DLS, DSF, SEC-MALS, mass photometry, fluorescence and luminescence-based assays.
  • Experience with antibody-drug conjugate (ADC) technologies is a plus, including familiarity with linker-payload strategies, conjugation methods, and biophysical and functional evaluation of ADCs.
  • Proven track record of scientific innovation and effective cross-functional collaboration, with the ability to drive projects forward in a dynamic biotech environment and communicate complex data clearly.

Job Tags

Similar Jobs

Express Employment Professionals

Call Center Agent - Inbound Job at Express Employment Professionals

 ...friendly voice our customers turn to for healthcare. In this role you will handle incoming calls providing helpful information resolving inquiries and ensuring a positive customer experience. Start within 2 weeks. Key Responsibilities : Handle a high volume of inbound... 

Foundations Education Solutions, A Member of the Point Quest...

Special Education Teacher Job at Foundations Education Solutions, A Member of the Point Quest...

 ...Special Education Teacher at Foundations Education Solutions, A Member of the Point Quest Group summary: A Special Education Teacher develops and implements adaptive lesson plans tailored to students with disabilities, ensuring alignment with IEP goals and state standards... 

BluePipes

Travel Nurse - LPN - Psych - Psychiatric - $1886.24 / Week Job at BluePipes

 ...MedStaff is seeking an experienced Psychiatric Licensed Practical Nurse for an exciting Travel Nursing job in Avondale, AZ. Shift: 5x8 hr...  .../ Week Atlas Medstaff is currently seeking candidates in the LPN/LVN, Psych profession for a 13 week contract in the Avondale, Arizona... 

Quality Carriers

Class - A CDL Dedicated Company Driver Job at Quality Carriers

 ...weekly bonus for the first 8 weeks of hire!Driver Referral Program - $6,000 for Each Driver...  ...Safety We keep you moving and safe!Truck Speeds 65 mph on the pedal, 68 mph on cruise...  ...covered Requirements: Valid CDL-A With Tanker anda Hazmat endorsement Currently... 

All Seniors

Dementia Care Specialist Job at All Seniors

Dementia Care Specialist - Providing Compassionate Support for Cognitive Health Company: All Seniors Foundation Location: Los Angeles, CA About Us: All Seniors Foundation is dedicated to enhancing the lives of older adults, including those experiencing memory loss and cognitive...